Seal circulation spray drying system works in a seal circumstance. The drying gas is usually inert gas, such N2.It's applicable for drying material with organic solvent, toxic gas and the material easy to be oxidized. adopt inert gas as circulation gas, so to protect the material to be dried. The inert gas circulates after dehumidification process. N2 is heated and then enters into drying tower. Liquid material is conveyed to centrifugal nozzle by screw pump, and then it's atomized into the liquid mist by the atomizer, the heat transferring process is finished in the drying tower. The dry product is discharged at the bottom of tower, the evaporated organic solvent is sucked by the vacuum generated by the fan. Power or solid material will be separated in the cyclone and sprinkling tower. The saturated organic gas is drained out after it's condensed in the condenser. The gas not condensed recycles in the system after it's heated continuously. Ordinary normal centrifugal spray drying process is realized by air conveying and exhausting process. This is the obvious difference between explosion proof type sealed circulation centrifugal spray dryer and ordinary centrifugal spray dryer. The drying media in drying system is N2, the interior is under positive pressure. To keep positive pressure stable, the pressure transmitter controls the inlet amount of N2 automatically.
A precise control of the drying process gives far greater command over the shape, density and morphology of the final product than other aseptic drying technology, and moreover, with low running and capital costs, these advantages are obtained while reducing overheads.
Production of dry sterile dosage forms often involves mixing of the API with one or more excipients. To achieve a homogeneous mixture, the particle size distribution of the excipient(s) must match that of the API. In a one-step-operation, aseptic spray drying can turn a sterile solution into sterile particles of the required size with no risk of introducing impurities.
The spray dryers are also designed for handling organic solvents, which makes possible the use of a wide range of excipients within the formulation.
The products once a time. After the drying process, there is no need for smashing and sorting, so as to reduce the operation procedures in the production and to enhance the product purity. The product particle diameters, looseness and water contents can be adjusted through changing the operation condition within a certain range.
ed centrifugal sprayer on the top of the tower, the material liquid will rotate and be sprayed into the extremely fine mist liquid beads. Through very short time of contacting the heat air, the materials can be dried into the final products. The final products will be discharged continuously from the bottom of the drying tower and from the cyclones. The waste gas will be discharged from blower.